Passano Foundation photo 2 4508225030_154x193.jpg



2017 Laureates


Cancer Virology Laboratory

University of Pittsburgh Cancer Institute



Dr. Yuan Chang and Dr. Patrick S. Moore discovered two independent causes of human cancer, Kaposi's sarcoma herpesvirus (KSHV/HHV8) and Merkel cell polyomavirus (MCV).  They used these discoveries to generate tests to detect these viruses and to uncover basic mechanisms involved in cancer cell formation.  In more than two decades, they are the only scientists to have found viral causes for cancer.  Their work has created new fields in cancer research and is used as a basis for investigating viral contributions to cancer.


Using two different genome scanning technologies (one of which they developed and is now commonly used by laboratories around the world), Chang and Moore isolated the DNAs of KSHV and MCV from human tumors.  They used these discoveries to isolate and grow the viruses in cell cultures, to develop blood and antibody tests, and to fully characterize the viruses. Their discoveries have had a fundamental impact in areas as diverse as innate immunity, cancer oncogene signaling, cellular protein processing, and virology.


2017 Physician Scientists

Ryan Felling, MD, PhD

Director, Pediatric Stroke Program

Assistant Professor of Neurology

Johns Hopkins School of Medicine



Mark Travassos, MD


Assistant Professor

University of Maryland School of Medicine



2016 Laureates

Helen H. Hobbs, MD

and Jonathan Cohen, PhD

Hobbs-Cohen Lab

Eugene McDermott Center

for Human Growth and Development

University of Texas

Southwestern Medical Center


Helen Hobbs, M.D. and Jonathan Cohen, Ph.D. focus their research program on the use of human genetics to identify genes that contribute to disorders of lipid metabolism and perform functional studies to define the underlying mechanisms.  Drs. Hobbs and Cohen are scientific partners at the University of Texas Southwestern Medical School in Dallas, where they direct research in the Departments of Internal Medicine and Molecular Genetics and in the Eugene McDermott Center for Human Growth and Development.  Dr. Hobbs is also an Investigator of the Howard Hughes Medical Institute.

For the past twenty years, Drs. Hobbs and Cohen have studied individuals with disorders of lipid uptake and trafficking who are at elevated risk for cardiovascular disease.  To identify underlying genetic risk factors, Dr. Hobbs established the Dallas Heart Study, a large and ethnically diverse group of individuals who participate in rigorous clinical assessment and comprehensive genetic testing.  By studying individuals with unusually high or low serum lipid levels, the Hobbs-Cohen team has identified critical genes - and their encoded proteins - that regulate lipid homeostasis.  This approach revealed the central role of PCSK9, a protein that degrades the receptor for low-density lipoprotein (LDL), in determining the level of serum cholesterol.  Remarkably, the Hobbs-Cohen work revealed that several million Americans have a genetic variant in one of their two PCSK9 genes that reduces or eliminates the activity of the encoded protein, leading to a modest reduction in circulating LDL and a dramatic reduction in the risk of atherosclerotic heart disease.



2016 Physician Scientists

Kaisorn Chaichana, M.D.


Johns Hopkins School of Medicine


Nancy Li Schoenborn, M.D.


Johns Hopkins School of Medicine



Andrea Berry, M.D.


University of Maryland School of Medicine




2015 Laureate

James P. Allison, Ph.D.

Chair, Department of Immunology

Director, Immunotherapy Platform

Deputy Director, David H Koch Center for Applied Studies in Genitourinary Cancer

Vivian L Smith, Distinguished Chair in Immunology

University of Texas MD Anderson Cancer Center



Dr. Allison's fundamental studies revealed the structure of the T cell receptor (TCR) at a protein level; he elucidated a role of CD28 as a key activator, and its counterpart CTLA-4 as a critical terminator of T cell responses.  Dr. Allison demonstrated that CTLA -4 frustrates anti-tumor immunity in experimental models and in cancer patients. He further demonstrated that antibody-mediated blockade of CTLA-4 allows for efficacious treatment of prostate, bladder, renal, ovarian, lung and breast cancers and of metastatic melanoma, where this treatment has become a standard of care.    This FDA approved drug is the first to increase survival of patients with metastatic melanomas and its success has inspired a revolution in cancer immunotherapy.


2015 Passano Physician Scientists

Channing Paller M.D.

Department of Oncology

Johns Hopkins School of Medicine


Simon Best, M.D.

Department of Otolaryngology

Johns Hopkins School of Medicine


David J. Riedel, M.D., M.P.H.

Institute of Human Virology

University of Maryland School of Medicine



2014 Laureate

Jeffrey I. Gordon, M.D.

Dr. Robert J. Glaser Distinguished University Professor

Director, Center for Genome Sciences & Systems Biology

Washington University School of Medicine


The work of Jeffrey I. Gordon, M.D., on the genomic and metabolic foundations of mutually beneficial host-microbial relationships in the human gut has helped create a new field of research, metagenomics. His studies of the interactions between the human gut microbiome and diet, and the role of the microbiome in defining our nutritional status at various stages of life,

have broad implications for 21st century medicine, as it further evolves its focus on disease prevention and new definitions of health. Dr. Gordon's work is providing both a new understanding of how changes in our cultural traditions and lifestyles are impacting our human

biology and new approaches for microbiome-directed therapeutics.


Dr. Gordon's research and leadership have been instrumental in launching human microbiome

projects throughout the world. His group has developed and applied innovative and powerful experimental and computational approaches to characterize our human gut microbial communities. These studies have provided a new and extended view of ourselves as a supraorganism (holobiont) composed of species from all three domains of 1 ife (and their viruses).


2014 Passano Physician Scientists

Janet L. Crane, M.D.

Department of Pediatrics

Johns Hopkins School of Medicine


Gabriel Ghiaur, M.D., Ph.D.      

Department of Oncology

Johns Hopkins School of Medicine


Mohammad Sajadi, M.D.

Institute of Human Virology

University of Maryland School of Medicine



2013 Laureate

Rudolf Jaenisch, Ph.D

Professor of Biology

Whitehead Institute and Dept. of Biology, MIT


Through his pioneering research in transgenic science, therapeutic cloning and cell biology, Jaenisch has consistently delivered paradigm-shifting breakthroughs to the world of biomedical research.  Jaenisch’s numerous important achievements include: the creation of the first transgenic mice for disease modeling; the first demonstration in mice that somatic cell nuclear transfer, in combination with gene therapy, could be a viable approach to treating a generic immune disorder; and the first proof-of-principle experiments showing that adult, differentiated cells reprogrammed in vitro to a pluripotent, embryonic stem cell-like state can be used to treat human diseases.


2013 Passano Physician Scientists


Jennifer Mammen, M.D., Ph.D.  

Division of Endocrinology

Johns Hopkins Bayview


Janis Taube, M.D., MSc.      

Departments of Dermatology and Pathology

Johns Hopkins School of Medicine


Graeme F. Woodworth, M.D.

Department of Neurosurgery

University of Maryland School of Medicine




2012 Laureate

Eric N. Olson Ph.D.


Eric Olson discovered key transcription factors and mechanisms responsible for heart development and disease.  His discoveries include the MEF2 transcription factor, which regulates differentiation of all muscle cell types; myocardin, a master switch for vascular muscle cell fate; and Hand1 and Hand2, which orchestrate the formation of the cardiac chambers.


2012 Passano Physician Scientists


Irina Burd, M.D., Ph.D.

Gynecology and Obstetrics

Johns Hopkins School of Medicine


Jonathon M. Gerber, M.D


Johns Hopkins School of Medicine


Kevin N. Sheth, M.D.

Stroke and Neuro-Critical Care

University of Maryland School of Medicine




2011 Laureate

Elaine Fuchs, Ph.D.


Elaine Fuchs is a world leader in skin biology and its human genetic disorders, which include skin cancers and life-threatening genetic syndromes such as blistering skin disorders. She is widely credited for bringing dermatology into the molecular biology era.



2011 Passano Physician Scientists


Gloria Reeves, M.D.

Assistant Professor, Child Psychiatry Division

University of Maryland


Adam Hartman, M.D., FAAP

Assistant Professor of Neurology & Pediatrics

Johns Hopkins School of Medicine


Aravindan Kolandaivelu, M.D.

Fellow in Cardiac Electrophysiology

Johns Hopkins Hospital



2010 Laureate

David Julius, Ph.D.


David Julius, Ph.D., a pioneer in sensory neurobiology, will receive the 2010 Passano Award for his discovery of the molecular mechanism of thermosensation and his elucidation of the manner in which temperature and pain sensation are integrated.  Dr. Julius’ research was conducted at the University of California at San Francisco, where he is Chairman of the Department of Physiology.


2010 Passano Physician Scientists


Marlis Gonzalez-Fernandez, M.D., Ph.D.

Johns Hopkins University School of Medicine

Assistant Professor, Department of Physical Medicine and Rehabilitation


Nilofer Azad, M.D.

Johns Hopkins University

Assistant Professor of Oncology


Afshin Parsa, M.D., M.P.H

University of Maryland School of Medicine, Baltimore, MD

Assistant Professor of Medicine




2009 Laureate

Irving L. Weissman, M.D.


Irving L. Weissman, M.D.,  Director of the  Stanford Institute of Stem Cell Biology and Regenerative Medicine, will receive the 2009 Passano Award for his ground-breaking contributions in the field of modern stem cell biology in the development of a general approach, now widely used, which has led to the isolation of all restricted lineage hematopoietic progenitors from mice and man.


2009 Passano Physician scientists


Mahendra Damarla, M.D.

Department of Medicine

Division of Pulmonary & Critical Care Medicine


Jason Farrar, M.D.

Johns Hopkins University

Department of Oncology

Pediatric Division


Ikwunga Wonodi, M.B.B.S

Assistant Professor, Department of Psychiatry

Maryland Psychiatric Research Center

University of Maryland, School of Medicine




2008 Laureate

Thomas C. Südhof, M.D.


Thomas Südhof, a Professor at the University of Texas Southwestern Medical School, received the 2008 Passano Award for his ground-breaking investigation of the biochemical composition of the synapse and his elucidation of the calcium-dependent mechanism of neurotransmitter release, one of the central events in brain function.  Neurons communicate at synapses by the controlled release of neurotransmitter from the pre-synaptic cell and the sensing of neurotransmitter by receptors on the surface of the post-synaptic cell.  Ever since the pioneering work of Bernard Katz half a century ago, it has been known that neurotransmitters are released in packets and that this release is controlled by calcium entry into the presynaptic neuron.  With the visualization of synaptic ultra-structure by electron microscopy, it became apparent that neurotransmitters were stored in presynaptic vesicles and that the release of a packet of neurotransmitter into the synaptic cleft is produced by the fusion of one of these pre-synaptic vesicles with the plasma membrane.  Therefore, a central mechanistic question is how presynaptic calcium entry controls vesicle fusion.


Twenty years ago, Südhof set out to answer this question by systematically identifying proteins that are enriched in presynaptic vesicles and plasma membrane.  This work led to his discovery of the synaptotagmin proteins as the calcium sensors that trigger vesicle fusion.  Using a combination of structural biology, electrophysiology, and gene manipulation in mice, Sudhof showed that cooperative calcium binding to the synaptotagmins produces rapid, efficient, and reliable control of neurotransmitter release  the three essential attributes of neurotransmission.


Südhof also pioneered the identification and analysis of molecules that control the formation of synapses during brain development.  In particular, he discovered a cell-surface receptor-ligand system  the neurexins and the neuroligins  that display enormous structural diversity and that play a central role in initiating the formation of pre- and post-synaptic structures.


Südhof's work on the molecular mechanisms of synaptic development and function have broad implications for human health, as current evidence suggests that many neuropsychiatric disorders arise from defects in synaptic development, function, and/or plasticity.


2008 Passano Physician scientists


Thomas E. Lloyd, M.D., Ph.D.

Johns Hopkins University

Department of Neurology

Neuromuscular Division


Edward Schaefer, M.D., Ph.D.

Johns Hopkins University

Department of Urology


Wilbur H. Chen, M.D.

University of Maryland

Assistant Professor



2007 Laureate

Joan Massagué, Ph.D.


Joan Massagué, Ph.D. of the Memorial Sloan-Kettering Cancer Center, will receive the 2007 Passano Award for the originality and importance of his work in elucidating the mechanism of TGF- action on diverse cell types: from receptor activation to signal transduction and to eventual activation of gene transcription, to discovering the first mamilian cyclin-dependant kinase inhibitor, p27, as an essential component of cell machinery, and more recently, the unraveling of the dichotomous role of TGF- in cancer: as a tumor suppressor in early-stage cancer and as a promoter of metastasis in later stages of tumor progression.  Foundation directors and colleagues applaud Dr. Massagués accomplishments.  Joans contributions to science, principal among them his elucidation of the steps in the TGF- signaling pathway, reflect an uncommon gift for scientific insight extended by first rate investigative skills, notes Harold Varmus, M.D., President of Memorial Sloan-Kettering Cancer Center of New York.  As a leader in the fields of both cancer biology and cell biology, much of Dr. Massagués recent work has also focused on the study of metastasis, the process by which cancer spreads from one part of the body to another. His laboratory has identified sets of genes that drive the spread of breast cancer to the bone and the lungs.


2007 Passano Physician scientists


Rachel Damico, M.D., Ph.D.

Johns Hopkins University

Department of Medicine

Division of Pulmonary and Critical Care Medicine


Andrew Mammen, M.D., Ph.D.

Johns Hopkins University

Department of Neurosurgery


Susanna Scafidi, M.D.

University of Maryland

Assistant Professor



2006 Laureate


Napoleone Ferrara, M.D., a pioneer in vascular biology received the 2006 Passano Award for the discovery of vascular endothelial growth factor (VEGF), the elucidation of VEGFs role in mammalian biology, and the development of anti-VEGF therapies for human disease.  Dr. Ferraras work was carried out at Genentech, a biotechnology company in South San Francisco, where he currently holds the position of Genentech Fellow in the Department of Molecular Oncology.



2006 Passano Physician scientists


Frances L. Johnson, M.D.

University of Maryland

Assistant Professor of Medicine

Medical Director, Heart Transplantation


Brett Morrison, M.D., Ph.D.

Johns Hopkins University

Neurology Research and Clinical Fellow


Alfredo Quiñones-Hinojosa, M.D.

Johns Hopkins University

Assistant Professor of Neurosurgery and Oncology




2005 Laureate

Jeffrey M. Friedman, M.D. Ph.D.

Marilyn M. Simpson Professor, Rockefeller University

Investigator, Howard Hughes Medical Institute


Jeffrey Friedman discovered the fat-cell hormone leptin and characterized its metabolic actions.  He proved through positional cloning of the Ob, or "obese", gene in mice that the gene product is a hormone-like polypeptide that he named leptin.



2005 Passano Physician Scientists


Bradley J. Goldstein, M.D., Ph.D.

Johns Hopkins University, School of Medicine



David J. Kouba, M.D., Ph.D.

University of Maryland Medicine



Wells A. Messersmith, M.D.

Johns Hopkins University, School of Medicine

Medical Oncology


Jennifer L. Payne, M.D.

Johns Hopkins University, School of Medicine



Sangeeta D. Sule, M.D., Ph.D.

Johns Hopkins University, School of Medicine

Pediatric Rheumatology



2003 Laureate

Andrew Z. Fire, Ph.D.


Member on the Carnegie Institution of Washingtons Department of Embryology in Baltimore, will receive the 2003 Passano Award for his discovery of RNA interference (RNAi), which must surely come to rank as one of the turning points in the history of genetics. This highly specific, RNA-directed method of gene silencing constitutes a fundamental and widespread new regulatory mechanism whose research and clinical applications are already being intensively explored.  



2003-2004 Passano Physician Scientists


Francesco Saverio Celi, M.D.


Obesity and insulin resistance are important risk factors for the development of cardiovascular disease. By first introducing the gene encoding the enzyme in a cell culture system, and secondarily introducing the gene encoding the enzyme in a cell culture system which responds to the beta-3-adrenergic stimulation, Dr. Cell will attempt to study the activity of this newly found mutant enzyme and its interaction with the beta-3-adrenergic stimulation. This research could lead to the development of specific therapies aimed toward a reduction of the obesity, insulin resistance and the related cardiovascular risk.


Joseph Mark Savitt, M.D., Ph.D.


Parkinson's disease results largely from the marked loss of the dopamine producing cells of the midbrain and the subsequent deficiency of dopamine in the striatum.  Because of ethical and practical concerns associated with the use of fetal brain tissue, the most common source of transplantable cells aimed at restoring this deficiency, Dr. Savitt is exploring the use of embryonic germ cells that could be manipulated to replace the dopaminergic cells lost in Parkinson's disease.


Tao Wang, Ph.D.


Mental retardation is the most common cause of handicaps in children and young adults. X-linked mental retardation (XLMR) occurs in 1 in 600 males and is genetically heterogeneous. Dr. Wang has developed a strategy of using a human X chromosome-specific cDNA microarray to identify responsible genes. Combined laboratory research and clinical training will help Dr. Wang develop a solid knowledge base and gain experiences in research and clinical care for patients with mental retardation.




Alexander Rich, M.D.

William Thompson Sedgwick Professor of Biophysics,

Massachusetts Institute of Technology


Dr. Rich was chosen for his seminal contributions to the current understanding of the biochemistry, structural biology, and biological function of nucleic acids, as well as to the current understanding of protein biosynthesis and the role of conformational change in DNA function, which have created the foundation for great strides in molecular biology, genetic engineering, and life sciences in general.




Seymour Benzer, Ph.D.

James Griffin Boswell Professor of Neuroscience, California Institute of Technology


Dr. Benzer was recognized for his pioneering contributions to molecular genetics and neurobiology.




Giuseppe Attardi, M.D.,

Grace C. Steele Professor of Molecular Biology, California Institute of Technology,


Douglas C. Wallace, Ph.D., Chairman, Department of Genetics and Molecular Medicine,

Emory University,


Drs. Attardi and Wallace were selected for their landmark contributions to the mitochondrial genome project and their development of innovative methods for studying mitochondrial genetics and human disease.




Elizabeth H. Blackburn, Ph.D.,

Professor and Chair of Microbiology

and Immunology

University of California,

San Francisco


Carol W. Greider, Ph.D.

Associate Professor of Molecular

Biology and Genetics  

Johns Hopkins University

School of Medicine


Drs. Blackburn and Greider were chosen  for determining the molecular nature of telomeres (chromosome ends) and discovering the enzyme telomerase, which carries out the synthesis of the telomeres.




H. Robert Horvitz, M.D., Ph.D.

Professor, Department of Biology

Massachusetts Institute of Technology


Dr. Horvitz was recognized for establishing that programmed cell death, a major  aspect of animal development, is an active biological process dependent on the functioning of particular genes.




James E. Darnell, Jr., M.D.

Vicent Astor Professor


Head of the Molecular Cell Biology Laboratory, Rochefeller University


Dr. Darnell was recognized for his breakthrough work identifying signal transduction pathways from the cell membrane to the nucleus. His work promises to be of landmark importance to greater understanding of polypeptides and cell growth, cell specialization in response to infection, and the maintenance of tissue homeostsis.




Leland H. Hartwell, M.D.

Professor of Genetics

University of Washington

Winner of the 2001 Nobel prize in Medicine


Dr. Hartwell was selected for his pioneering insights into the life cycle of the cell and its role in the development of cancers. He was the first to identify the molecules that regulate cell division, and developed and proved the concept of cell cycle checkpoints.




Robert G. Roeder, Ph.D.

Professor and Head, Laboratory of Biochemistry and Molecular Biology, The Rockefeller University


Robert Tijan, Ph.D.

Professor of Molecular and Cell Biology, University of California at Berkeley


Drs. Roeder and Tijan were selected for their independent, fundamental contributions to the understanding of the biochemistry of transcription, the process by which genetic information encoded in DNA is transferred to the RNA molecules that control the synthesis of cellular proteins.




Bert Vogelstein, M.D.

Professor of Oncology

Johns Hopkins University

School of Medicine


Dr. Vogelstein was selected for his seminal contributions to the understanding of human tumorigenesis. He was the first to demonstrate the importance of a series of specific losses in function of key tumor suppression genes, and the activation of known oncogenes in the progressive transformation of normal colonic epithelial cells into fully invasive colon carcinomas.




Jack L. Strominger, M.D.

Professor of Biochemistry


Don C. Wiley, Ph.D.

Professor of Biochemistry and Biophysics, Harvard University


Drs. Strominger and Wiley were selected for their contributions to the understanding of the human immune response. Their discovery is a milestone in molecular immunology, comparable to the elucidation of the structure of antibodies three decades ago.




Charles Yanofsky, Ph.D.

Herzstein Professor of Biology,

Stanford University


Dr. Yanofskys work demonstrated the relationship between the structure of genes and proteins. He conducted studies of microbial gene expression that led to the discovery and elucidation of the phenomenon of attenuation.


Young Scientist Award

Tom Curran, Ph.D.

Associate Director,

Roche Institute of Molecular Biology,

Head, Department of Molecular Oncology and Virology,

Roche Institute of Molecular Biology


Dr. Curran has made significant contributions in the field of molecular oncology, including pioneering work on the role of the fos and jun oncogenes in the regulation of transcription.




William S. Sly, M.D.

Professor of Biochemistry, St. Louis University School of Medicine and Stuart Kornfeld, M.D.

Department of Internal Medicine,

Washington University School of Medicine


Drs. Sly and Kornfeld were honored for their elucidation of the pathway by which lysomal enzymes are targeted to their specific location within lysomes.


Young Scientist Award

Roger Tsien, Ph.D.

Professor of Pharmacology

and Chemistry,

Univesity of California, San Diego


Dr. Tsien was honored for his development of the methodology for measuring changes in calcium levels in living cells.




Young Scientist Award

Matthew P. Scott, Ph.D.,

Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder


Dr. Scott was honored for his pioneering work on the molecular basis of development.




Victor A. McKusick, M.D.,  

University Professor of Medical Genetics,  

Johns Hopkins University

School of Medicine  


Dr. McKusick was recognized for his important contributions to the field of medical genetics.  


Young Scientist Award  

Louis M. Kunkel, Ph.D.,  

Associate Professor of Pediatrics

Harvard Medical School


Dr. Kunkel was honored for his discovery of the genetic defects responsible for Duchenne muscular dystrophy.




Edwin G. Krebs, M.D.,  

Senior Investigator,  


Edmond H. Fischer, Ph.D.,  

Professor of Biochemistry, University of Washington, School of Medicine

Winners of the 1992 Nobel prize in Medicine


Drs. Krebs and Fischer were honored for their pioneering studies on the role of protein phosphorylation/dephosphorylation cycles in cellular regulation.  


Young Scientist Award  

Peter Walter, Ph.D.,  

Department of Biochemistry and Biophysics  

University of California School

of Medicine, San Francisco


Dr. Walter was recognized for his characterization of a signal recognition particle that identifies newly synthesized proteins and directs them to their membrane locations.  




Irwin Fridovich, Ph.D.,  

Professor of Biochemistry,  

Duke University Medical Center  


Dr. Fridovich was recognized for his discovery of the biological significance of oxygen radicals and the mechanisms employed by living things to defend themselves against the toxic effects of these radicals.  


Young Scientist Award  

Jeremy Nathans, Ph.D.,  

Department of Biochemistry,  

Stanford University School of Medicine  


Dr. Nathans was honored for the isolation of the genes that specify the protein moieties of the three different color-sensitive pigments in the human eye, and his contributions to the molecular genetics of abnormalities in color vision.




Albert Lester Lehninger, Ph.D.,  

University Professor of Medical Sciences, Johns Hopkins University,  

School of Medicine and  

Eugene Patrick Kennedy, Ph.D.,  

Hamilton Kuhn Professor and Director  

of the Department of Biological  

Chemistry, Harvard Medical School  




Howard Green, M.D.,  

Professor of Pathology and Biophysics,  

Harvard Medical School  


Dr. Green was honored for his pioneering research in cell biology.  


Young Scientist Award  

Mark M. Davis, Ph.D.,  

Assistant Professor of Medical  

Mycology, Stanford University  


Dr. Davis was recognized for his discovery of the genes that encode the antigen receptors of T lymphocytes.  



Dr. Lehninger was recognized for his many important contributions to bioenergetics and its relation to mitochondrial calcium metabolism and to proton transport.  


Dr. Kennedy was honored for his highly original contributions to the understanding of the mechanism of synthesis of complex lipids and of the function and organization of cellular membranes.  


Young Scientist Award  

James Edward Rothman, Ph.D.,  

Professor of Biochemistry, Stanford  

University School of Medicine  


Dr. Rothman was recognized for his clarification of the functions of a specific and highly characteristic set of stacked intracellular membranes known as the Golgi apparatus.  




Peter C. Nowell, M.D.,  

Professor of Pathology, University of  

Pennsylvania School of Medicine,  



Dr. Nowell was honored for the discovery of the first characteristic and consistent chromosomal abnormality in cancer cells (the abnormality known as the Philadelphia chromosome).  


Young Scientist Award  

Thomas R. Cech, Ph.D.,  

Professor of Chemistry,

University of  Colorado, Boulder

Winner of the 1989 Nobel prize in Chemistry


Dr. Cech was recognized for his highly original discovery that nucleic acids (RNA) are capable of catalyzing their own splicing reactions in the absence of conventional enzymes.  




J. Michael Bishop, M.D.  


Harold E. Varmus, M.D.,  

Professors of Microbiology,  

University of California School  

of Medicine, San Francisco

Winners of the 1989 Nobel prize in Medicine


Drs. Bishop and Varmus were honored in recognition of their pioneering research on the molecular biology of tumor viruses, and in particular for their key discovery that the cancer-causing genes (oncogenes) of a major class of tumor viruses are present as normal components of the chromosomes of all vertebrates, including man.  

Young Scientist Award  

Gerald M. Rubin, Ph.D.  


Allan C. Spradling, Ph.D.,  

Staff Members of the Department  

of Embryology, Carnegie

Institution of Washington  




Roscoe O. Brady, M.D.,  

Chief, Developmental and Metabolic  

Neurology Branch, National Institute of Neurological and Communicative  

Disorders and Stroke, National  

Institutes of Health  


Elizabeth F. Neufeld, Ph.D.,  

Chief, Genetics and Biochemistry  

Branch, National Institute of Arthritis, Metabolism and Digestive Diseases,  

National Institutes of Health  


Dr. Brady was selected for elucidating the molecular basis of a series of hitherto incurable hereditary diseases of complex lipid metabolism.  


Dr. Neufeld was chosen for her contributions to the understanding of the molecular basis of a group of hereditary diseases known as mucopolysaccharide storage diseases.  


Young Scientist Award  

Roger D. Kornberg, Ph.D.,  

Professor of Structural Biology, Stanford University  


Dr. Kornberg was recognized for his contributions to the current understanding of the structure of chromatin.  


Drs. Rubin and Spradling were chosen for their outstanding research in developmental genetics.  




Hugh O. McDevitt, M.D.,  

Professor of Medicine, Stanford  

University School of Medicine


Dr. McDevitt was recognized for his research on the relationships between the immune response, histocompatibility antigens and human disease.  


Young Scientist Award  

William A. Catterall, Ph.D.,  

Associate Professor of Pharmacology, University of Washington

School of Medicine  


Joel Moss, M.D., Ph.D.,  

Head, Section of Molecular Mechanisms,  

Laboratory of Cellular Metabolism,  

National Heart, Lung,

and Blood  Institute,

National Institutes of Health  


Dr. Catterall was selected for his pioneering contributions to the understanding of the relationship of ion transport to electrical excitability.  


Dr. Moss received the Award for his contribution to an understanding of the action of bacterial toxins and his exemplary combination of clinical and scientific skills.  




Seymour Solomon Kety, M.D.,  

Professor of Psychiatry,

Harvard University  


Dr. Kety received the Award for his original and creative contribution to our knowledge of brain function and the biology of mental illness.  




Donald F. Steiner, M.D.,  

Professor and Chairman, Department of Biochemistry, University of Chicago


Dr. Steiner discovered the mechanism by which insulin is synthesized in the body.  

Young Scientist Award  

Richard Axel, M.D.,  

Professor of Biochemistry and Pathology,  

Institute for Cancer Research, Columbia University, New York  


Dr. Axel was selected for his research on gene transfer in cultured mammalian cells.  




Michael S. Brown, M.D.,  


Joseph L. Goldstein, M.D.,  

Professors of Medicine, University of  

Texas Southwestern Medical Center

Winners of the 1985 Nobel prize in Medicine


Drs. Brown and Goldsteins insights into the pathogenesis of atherosclerosis resulted in reappraisal of its prevention and treatment.  


Young Scientist Award  

Robert J. Lefkowitz, M.D.,  

Professor of Medicine,

Duke University  


Dr. Lefkowitzs work added substantially to current understanding of hormonal control mechanisms.  




Curt P. Richter, Ph.D.,  

Professor Emeritus of Psychobiology,  

Johns Hopkins University

School of Medicine  


Dr. Richter made many outstanding and fundamental contributions to knowledge in psychology, physiology, neurology and endocrinology.  


Young Scientist Award  

Eric A. Jaffe, M.D.,  

Assistant Professor of Medicine,  

Cornell University Medical College  


Dr. Jaffe made fundamental discoveries in the general area of blood coagulation physiology and biochemistry.




Roger Guillemin, M.D., Ph.D.,  

Professor, The Salk Institute

Winner of the 1977 Nobel prize in Medicine  


Dr. Guillemins pioneering research provided decisive evidence which demonstrated control by the hypothalamus of release of pituitary hormones.  


Young Scientist Award  

Ralph A. Bradshaw, Ph.D.,  

Professor of Biochemistry, Washington  

University School of Medicine  


Dr. Bradshaws extensive accomplishments related protein structure and function, most notably, dehydrogenase enzymes and nerve growth factor.




Henry G. Kunkel, M.D.,  

Professor, Rockefeller University  


Dr. Kundels fundamental research on human immunoglobulins helped establish the field of immunogenetics.  


Young Scientist Award  

Joan Argetsinger Steitz, Ph.D.,  

Associate Professor, Yale University  


Dr. Steitz research on protein biosynthesis provided a deeper understanding of cellular regulatory mechanisms of viral infections and of antibiotic action.  




Seymour S. Cohen, Ph.D.,  

Professor of Microbiology, University of Colorado, School of Medicine, Denver  


Dr. Cohen pioneered studies of virus development and the effects of viruses on cellular metabolism.  


Baruch S. Blumberg, M.D., Ph.D.,  

Associate Director of Clinical Research, The Institute for Cancer Research, Fox Chase, Philadelphia  


Dr. Blumbergs seminal studies on hepatitis-associated antigen opened a new era of research on viral hepatitis.  




Roger W. Sperry, Ph.D.,  

California Institute of Technology,  

Division of Biology  

Winner of the 1981 Nobel prize in Medicine  


Dr. Sperry discovered an unexpected specificity in the recognition of one neuron by another, and he offered new insights into the functions of the surgically disconnected hemispheres, first in animals, then in human patients operated upon for intractable epilepsy. He made fundamental contributions to our understanding of the mind/brain relation and the neurologic bases of human behavior.  




Kimishige Ishizaka, M.D.,  


Teruko Ishizaka, M.D.,  

Johns Hopkins University School of  

Medicine, Immunology Division


Drs. Ishizaka received the Award for their fundamental research into the cause and mechanism of allergic reactions.  Working as a team, they have investigated many aspects of the antibodies which cause human allergy, research which had led to the discovery of a new class of immunoglobulins, IgE, which are responsible for the disease process.  This work opened a new era of research into hypersensitivity reactions at all levels, biochemical, pathogenetic and clinical.




Stephen W. Kuffler, M.D.,  

Chairman and Robert Winthrop  

Professor of Neurobiology,

Harvard Medical School


Dr. Kufflers work includes analyses of how information is transmitted from one cell to another, how it is analyzed in the nervous system and how muscle movement is controlled and executed. From his early research in neuromuscular transmission processes, he went on to an investigation of the chemistry of synaptic inhibitory transmission, which led to the discovery of gamma-aminobutyric acid as a synaptic transmitter of inhibition in Crustacea.  




Paul Charles Zamecnik, M.D.,  

Massachusetts General Hospital  


Dr. Zamecniks pioneering investigations opened the process of protein synthesis to direct study, free from the structure of the intact cell, and led to the identification of the role of the ribosome, the amino acid activation reaction and transfer ribonucleic acid in protein synthesis.  




George Herbert Hitchings, Ph.D.,  

Vice-President, in Charge of Research,  

Burroughs Wellcome & Company

Winner of the 1988 Nobel prize in Medicine


Dr. Hitchings showed exemplary leadership in the rational application of the antimetabolite concept, in conjunction with exploration of differences in the enzymatic machinery of host and parasite, to the design of clinically important chemotherapeutic agents for immunosuppression and for therapy of leukemia, gout and malaria.  




John Eager Howard, M.D.,  

Professor of Medicine, Johns Hopkins  

University School of Medicine  


Dr. Howard was recognized for his distinguished contributions over many years in the etiology of arterial hypertension and the metabolism of calcium and its endocrine control. In particular, he was honored for the discovery of chemical factors in the blood and urine that could inhibit renal stone formation and other calcification processes.  




Irvine H. Page, M.D.,  

Research Consultant,

Cleveland Clinic Foundation  


Dr. Page was honored for his outstanding contributions to the understanding of the pathogenesis and pathophysiology of hypertension, a disease condition related to many illnesses.  He has served on the boards of many professional societies.  




John T. Edsall, M.D.,  

Professor of Biological Chemistry,  

Harvard University  


Dr. Edsall was acknowledged for his incisive experimental achievement in analyzing the physical-chemical basis of the structure and biologic activity of amino acids, peptides and proteins; his influential leadership in fostering the physical-chemical approach to biochemical problems; and his service to biochemistry and medical science through professional societies.




Charles B. Huggins, M.D.,  

Director, Ben May Laboratory for  

Cancer Research, Chicago

Winner of the 1966 Nobel prize in Medicine


The Award was bestowed on Dr. Huggins for his contributions to the knowledge of the role of hormones in the induction and control of cancer.  He discovered the use of female hormones in cancer of the prostate. In addition, he has worked on calcium metabolism, blood enzymes, bone physiology, experimental surgery and cancer research.  




Keith R. Porter, Ph.D.,  

Professor of Biology,  

Harvard University  

George E. Palade, M.D.  

Member and Professor of Cytology,  

The Rockefeller University

Winner of the 1974 Nobel prize in Medicine  


Drs. Porter and Palade shared the Award in recognition of their original work in developing the use of the electron microscope in cytologic research and the subsequent importance of their work in the field of genetics.  The techniques and applications which they developed became extremely valuable to researchers in cytogenetics and cell biology.  




Horace W. Magoun, Ph.D., D.Sc.,  

University of California School of  Medicine, Los Angeles  


Dr. Magoun received recognition for his studies in neurophysiology and anatomy, especially his discovery concerning the influence of activity of the reticular formation of the brain on the activity of the brain proper.  




Albert H. Coons, M.D.,  

Harvard Medical School  


Dr. Coons contribution to scientific medicine was the development of fluorescent antibodies, which allow the microscopic localization and identification of infectious bacteria and viruses, foreign proteins in animal cells, structural materials of animal cells and the general application of immunologic specificity on a microscopic scale.  




Owen H. Wangensteen, M.D.,  

Professor and Head of Department of  

Surgery, University of Minnesota  

Medical School  


Dr. Wangensteen received the Award for his many contributions to surgical technique and postoperative care of the patient. He developed a gastrosuction device to relieve distention in cases of intestinal obstruction, and a procedure to circulate an ethanol solution in a balloon inside the stomach, thus making surgical relief feasible, or unnecessary, for patients with bleeding duodenal ulcers.  




Rene J. Dubos, Ph.D.,  

Member and Professor of Pathology,  

Rockefeller University  


Dr. Dubos was chosen because of his many and fruitful researches in bacteriology and biochemistry, notably the use of specific enzymes in biochemistry, the chemotherapy of tuberculosis and pioneer work on antibiotics from soil organisms.  




Stanhope Bayne-Jones, M.D., Sc.D.,  

Formerly Technical Director of  

Research, Office of the Surgeon General  


Dr. Bayne-Jones was recognized because of a long and extraordinary service to science both as educator and administrator.  His distinguished career included the deanship of the Yale University School of Medicine, presidency of the Joint Administration Board of the New York Hospital-Cornell Medical Center, of The Society of American Bacteriologists, the American Association of Immunologists and the American Association of Pathologists and Bacteriologists.  




George Washington Corner,

M.D., D.Sc.,  

Executive Office, American  

Philosophical Society  


Dr. Corner, Sr., was honored because of his long and distinguished career as investigator, educator, historian, and philosopher of science.  He has served at the University of California, at Johns Hopkins Medical School, was Professor of Anatomy at Rochester School of Medicine and Director of the Department of Embryology at the Carnegie Institution.  




Williams Mansfield Clark,

Ph.D., Sc.D.,  

DeLamar Emeritus Professor and  

Research Professor of Chemistry,  

Johns Hopkins University